The TC5123 hepatoma showed a significantly ( P < 0.002) higher mean SUV at 5 and 70 min post-5-FU injection than the MH3924A cell lines, whereas there were no significant differences between the mean SUV measured in the liver of both animal populations.
To allow a comparison between PET and MRI data, SUVs were computed at the same points in time. After administration of 5-FU, the kinetics of the regional 5-FU uptake was measured by dynamic PET scanning over 120 min. Selective 5-FU and alpha-fluoro-beta-alanine (FBAL) MR images were acquired 5 and 70 min after 5-FU injection using a chemical shift selective (CHESS) MRI sequence.
The potentials and limitations of dynamic 18F PET and metabolic 19F MRI examinations for noninvasive 5-FU monitoring were investigated. 116 radiolabeled and studied the anticancer drug 5-FU in ACI and Buffalo rats with transplanted MH3924A and TC5123 Morris hepatomas. Smith-Jones, in Comprehensive Medicinal Chemistry II, 2007 3.31.4.6.1 Direct measurementsīrix et al. When only the refractive index is given, it is necessary to use a conversion table to show the cut-out Brix. Some refractometers have a sugar scale, which will also show the Brix direct. The cut-out Brix may also be determined with a refractometer. When the hydrometer has come to rest in the syrup in the cylinder, the reading should be taken at the level of the liquid rather than where the liquid rises around the stem of the hydrometer. The hydrometers should be graduated at 20 ☌ rather than any lower temperature. A glass or metal cylinder of about 200-ml capacity should also be available. Two hydrometers should be provided, one reading from 10 to 20% and the other from 20 to 30%. The cut-out Brix may be determined with a Brix hydrometer. The cut-out Brix of successive containers can show large variations. With large units, such as large half-pears, the weight of fruit that can be put in each container varies greatly. With small units, such as cherries, the weight of fruit and of added syrup in each can is quite uniform and the cut-out Brix of successive containers will be similarly close to each other. (10.6) ( Ingoing fruit mass × ° Brix fruit ) + ( mass of ingoing syrup × ° Brix syrup ) = ( total mass of product in container × target cut - out Brix ) Sugar per berry calculations yield considerably more information than that available by evaluation of ☋rix measurements alone. However, sugar per berry calculations could lead to a different conclusion if there were changes in berry weight ( Table 4.2).
For example, if data were taken from the same vineyard at five-day intervals and the soluble solids (☋rix) of both sample dates measured 22 ☋rix, it might be concluded that there had been no change in fruit maturity. The concept of sugar per berry utilizes a soluble solids evaluation, such as ☋rix, and takes into account the weight of a berry sample. However, this can be difficult to monitor where fruit maturity is not uniform across clusters or berries. Once phloem transport has ended, any further increases in ☋rix will be due to loss of water, not continued synthesis, and translocation of sugar.Īssessing changes in berry weight, and noting the point at which average berry weight starts to decrease, while ☋rix increases, can indicate the onset of dehydration. It is important to be able to distinguish transient effects from the permanent cessation of transport of photosynthates. Sugar accumulation may cease due to unfavourable environmental conditions, such as very high or low vineyard temperatures, but resume once conditions have changed. Major increase: maturation and dilution (b)
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